SampledSphere

Resources

Events

Careers

Contact

  • Enquire
  • Services
    • Our labs are your labs

      Sample storage

      • Biobanking Services
      • ICH Stability Storage
      • Photostability Testing
      • Sample Data Storage
      • SampledSphere™

      Sample Management

      • Sample Lifecycle Management
      • Sample Data Management
      • Program Management

      Multiomics

      • Analytical Sample Processing
        • Extraction
        • Blood Fractionation
        • Normalization
        • Sample Processing Quality Control
        • Aliquoting
      • Sequencing
        • Whole-Genome Sequencing
        • Whole Exome Sequencing
        • Targeted Sequencing
        • Sanger Sequencing
        • RNA Sequencing
        • Methylation Sequencing
        • Protein Biomarker Discovery
      • Microarrays
        • Genotyping Arrays
        • Transcriptome Profiling Arrays
        • Methylation Profiling
      • PCR
        • Droplet Digital PCR
        • qPCR
      • Bioinformatics
        • Bioinformatics Analysis
        • Bioinformatics Custom Reporting

      Cellular Services

      • Cell Sample Processing
        • PBMC Isolation
        • Lymphoblastoid cell lines (LCL) Generation & Expansion
        • Fibroblast Generation and Expansion
      • iPSC Services
        • iPSC Reprogramming
        • iPSC Gene Editing
        • iPSC Expansion
        • Neural Progenitor Cell (NPC) differentiation
        • iPSC Quality Control
      • Histology
      • Cell Line Repositories

      Kitting & Logistics

      • Custom Clinical Kitting
      • Sample Logistics
      • Technical Services
      • Validation Services
  • Technology
    • Partner with Sampled and move forward, faster

      Illumina
      Olink
      whole genome sequencing pacbio

      Learn about Service Provision at Sampled

      Our partnerships enable us to provide our clients with access to technology immediately, without the initial overheads and complexities of setting up their own labs. 

      John DelliSanti

      Chief Executive Officer

  • Applications
    • Supporting a wide range of applications:

      Oncology

      Genetic Disorders

      Neurodegenerative Diseases

      Cardiovascular Diseases

      Infectious Diseases

      Autoimmune Diseases

      Metabolic Disorders

      Inflammation

      Substance Abuse

      Our commitment to supporting a wide range of applications, from oncology to substance abuse, underscores our dedication to advancing healthcare and improving patient outcomes across diverse medical challenges.

      View all application areas

      John DelliSanti

      Chief Executive Officer

  • About
    • Learn more about our mission, approach & standards

      About sampled

      Learn more

      Meet the team

      Learn more

      Join the team

      Learn more

      Our Facilities

      Learn more

      Clients Partners

      Learn more
  • Blog
    • News and insights from Sampled and the wider industry

      How Technology Partners Are Pioneering the Future of Genomic Medicine

      May 13, 2025

      Sampled Obtains Wholesale Distribution Authorisation (WDA) Licensing, Expanding Storage Services to the Pharmaceutical and Medical Device Sectors

      April 30, 2025

      Sampled Partners with EBiSC to Expand Access to Stem Cell Lines in the US

      April 8, 2025

      Join us on our blog where we share our passion for unraveling the science of precision medicine, offering practical knowledge and applications from over 25 years of experience in analytical and biorepository services.

      View all our blog posts here

      Mike Sheldon

      Senior Director Scientific Affairs

Search
START TYPING AND PRESS ENTER TO SEARCH
  • Enquire
  • Services
    • Sample Storage
    • Sample Management
    • Multiomics
    • Cellular Services
    • Kitting & Logistics
  • Technology
  • Applications
  • About
  • Blog
  • Resources
  • Careers
  • Events
  • Contact
Search
  • Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to footer

Impact of the NINDS Biorepository on Advancing Cellular Research

November 13, 2024 admin

The National Institute of Neurological Disorders and Stroke (NINDS) is an invaluable asset in advancing cellular research on neurological disorders.

By providing access to a diverse collection of high-quality patient-derived cell lines, NINDS facilitates breakthroughs in understanding diseases like Alzheimer’s and amyotrophic lateral sclerosis (ALS).

Partnering with SAMPLED for secure storage and efficient distribution, NINDS supports researchers worldwide in developing novel treatments and expanding knowledge in the field. This blog explores the impact of the NINDS Biorepository on cellular research and the crucial role of advanced biobanking practices, such as those implemented by SAMPLED, in preserving the integrity of these essential resources.

The National Institute of Neurological Disorders and Stroke

NINDS supports furthering our understanding of neurological disorders through education, funding, and its biorepository1. The NINDS biorepository maintains a diverse set of patient-derived cell lines, including induced pluripotent stem cells (iPSCs) and fibroblasts for many neurological disorders such as Alzheimer’s disease. By providing high-quality cell lines for research and clinical trials, NINDS enables researchers to derive crucial information about neurological disorders and promotes the generation of novel therapies and management strategies. NINDS relies on SAMPLED as a trusted partner to securely store and distribute cells.

Sample Storage Challenges in Modern Research

Research institutions face several challenges when storing samples and reagents. Small institutions can struggle with capacity and having sufficiently skilled staff to manage storage infrastructure and data security, while large institutions can struggle with adapting their existing infrastructure to evolving research environments. For instance, personalized medicine and the discovery of biomarkers for neurological diseases from diverse tissue types mean that more samples may need to be stored for individual patients2–4.

The high volume of samples necessitates more automated approaches to sample security. Manual monitoring becomes increasingly inefficient and unreliable as the volume of samples increases. Institutions like NINDS possess highly valuable cell lines sensitive to temperature fluctuations. Thus, they have an increased need for robust systems to ensure sample integrity. Beyond physical security, biorepositories require robust cybersecurity measures to safeguard patient data. In addition to protecting data, it is essential that samples and their related information are well-organized and readily accessible to authorized personnel.

Benefits of Advanced Biobanking

Advanced biobanking systems, such as those employed by SAMPLED in its partnership with NINDS, help to overcome many of these challenges, offering enhanced sample quality and security to bolster research efforts.

Scalability

Flexible storage capacity is essential for optimal biobanking and allows researchers to tackle more ambitious research projects incorporating more patient samples, treatments, and timepoints.

Security

Modern biobanks incorporate robust physical and data security systems to ensure patient data and samples are handled appropriately and are less vulnerable to theft or loss due to disasters. These systems include data encryption, dedicated alarm systems, real-time monitoring, and adherence to international regulatory standards such as the International Society for Biological and Environmental Repositories (ISBER)5 and the Health Insurance Portability and Accountability Act (HIPAA)6.

Automation

Modern biobanks use automation to streamline the retrieval and processing of different samples. This helps to eliminate the chances of human error, which can accelerate sample degradation and lead to sample misplacement.

The SAMPLED Framework

SAMPLED is the dedicated supplier for the NINDS Human Cell and Data Repository (NHCDR) and is trusted by other government institutions for sample storage and distribution. SAMPLED maintains a modern sample collection, storage and analysis infrastructure to help streamline the next generation of therapies for neurological disorders.

Automation

SAMPLED uses high-end automated instrumentation throughout its sample collection and storage pipeline. This helps ensure samples are stored at optimal temperatures, giving the best chances for high-quality data.

Security

SAMPLED uses dedicated alarm systems and real-time monitoring for each of its 600 mechanical -80°C freezers to ensure samples are always maintained appropriately. SampledSphere is our Title 21 CFR part 117 and HIPAA-compliant cloud-based portal where clients can view their data and receive reporting tailored to their needs.

Ordering NINDS Cell Lines

SAMPLED facilitates efficient ordering of cell lines from NINDS to drive the next generation of treatments for neurological disorders.

Visit this page for a detailed guide.

Conclusion

The NINDS Biorepository, bolstered by its partnership with SAMPLED, is transforming cellular research by providing researchers with secure, high-quality, patient-derived cell lines. This resource accelerates breakthroughs in understanding neurological disorders and developing novel therapies.

With advanced biobanking practices, including automated storage, robust data security, and scalable infrastructure, NINDS ensures the preservation and accessibility of critical research materials. As a result, the biorepository plays a pivotal role in advancing scientific knowledge and treatment possibilities for neurological diseases.


Do you need high-quality cell lines for your neurology research?

Download our comprehensive whitepaper, which covers the importance of NINDS and advanced biobanking practice in more detail.

Download white paper

References

1. The NINDS Human Cell and Data Repository – Providing iPSCs and Fibroblasts for the Study of Neurological Disease. March 1, 2021. Accessed October 29, 2024. https://nindsgenetics.org/

2. Zeng X, Chen Y, Sehrawat A, et al. Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting. Mol Neurodegener. 2024;19(1):40. doi:10.1186/s13024-024-00711-1

3. Jiao LL, Dong HL, Liu MM, et al. The potential roles of salivary biomarkers in neurodegenerative diseases. Neurobiology of Disease. 2024;193:106442. doi:10.1016/j.nbd.2024.106442

4. Król-Grzymała A, Sienkiewicz-Szłapka E, Fiedorowicz E, Rozmus D, Cieślińska A, Grzybowski A. Tear Biomarkers in Alzheimer’s and Parkinson’s Diseases, and Multiple Sclerosis: Implications for Diagnosis (Systematic Review). Int J Mol Sci. 2022;23(17):10123. doi:10.3390/ijms231710123

5. ISBER. Accessed October 30, 2024. https://isber.org

6. CDC. Health Insurance Portability and Accountability Act of 1996 (HIPAA). Public Health Law. September 10, 2024. Accessed October 30, 2024. https://www.cdc.gov/phlp/php/resources/health-insurance-portability-and-accountability-act-of-1996-hipaa.html

7. CFR – Code of Federal Regulations Title 21. Accessed October 30, 2024. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=11

Filed Under: Cellular Services

Primary Sidebar

Share this

  • Share on Twitter Share on Twitter
  • Share on Facebook Share on Facebook
  • Share on LinkedIn Share on LinkedIn
  • Share via Email Share via Email

Other recent posts

  • How Technology Partners Are Pioneering the Future of Genomic Medicine
  • Sampled Obtains Wholesale Distribution Authorisation (WDA) Licensing, Expanding Storage Services to the Pharmaceutical and Medical Device Sectors
  • Sampled Partners with EBiSC to Expand Access to Stem Cell Lines in the US
  • Sampled Selected as Genome Characterization Center for the NCI
  • Why Outsourcing -80°C Freezer Storage Could Save Your Lab Money

Footer

Sampled logo

Sampled
30 Knightsbridge Road
Building 3, Piscataway, NJ 08854
U.S.A

Tel:  +1-732-273-0699

Latest news

  • How Technology Partners Are Pioneering the Future of Genomic Medicine May 13, 2025
  • Sampled Obtains Wholesale Distribution Authorisation (WDA) Licensing, Expanding Storage Services to the Pharmaceutical and Medical Device Sectors April 30, 2025
  • Sampled Partners with EBiSC to Expand Access to Stem Cell Lines in the US April 8, 2025

Keep up to date

Connect with us on Linkedin

Sign up for our newsletter

Search site

Copyright © 2025 Sampled.com | Legal | Privacy policy | Cookies | Web build by...

Infinity BiologiX LLC, Roylance Stability Storage Limited and Roylance Scientific Limited are doing business as Sampled.

Speak to an expert

Tell us about your requirements and you will be contacted by our staff for personalized assistance

Speak to an expert

Tell us about your requirements and you will be contacted by our staff for personalized assistance

Sign up for our newsletter

Enquiry form

Search sampled.com

Free sample pack

Fill out the form below to receive a sample kitting pack with packaging examples and more information. 

Learn more about our kitting services