The Critical Role of Pre-analytical Work in Ensuring Data Integrity in Clinical Trials and Longitudinal Studies

Pre-analytical work encompasses sample collection, processing, handling, storage, and analytical considerations, each pivotal in preserving the integrity and quality of biospecimen. This whitepaper explores the challenges, methodologies, and quality control measures integral to the pre-analytical stage, highlighting the substantial impact these factors have on the accuracy, reproducibility, and reliability of research findings. Additionally, it explores the role of the Global Integrated Analytical Biorepository (GIAB) in revolutionizing biobanking practices.