The Impact of PBMC Isolation Precision on Study Outcomes

The field of immunology touches key therapeutic areas like oncology, autoimmune diseases, infectious diseases, and transplantation, establishing it as a cornerstone of modern therapeutics.

Immune cell therapies represent the forefront of medical treatments, with peripheral blood mononuclear cells (PBMCs) playing a crucial role in advancing this field. Despite promising advancements, many factors in PBMC isolation can significantly affect the results of downstream studies and delay therapy development. As living cells, PBMCs are inherently sensitive to their environment and to different isolation processes, which can alter their function and viability. Furthermore, isolating PBMCs from blood poses the risk of contamination with other cell types that impede downstream experimentation. Sampled’s Global Integrated Analytical Biorepository (GIAB) offers streamlined, integrated, and high-capacity PBMC isolation and analysis processes. Standardized procedures within the GIAB framework control for the variables inherent to PBMC isolation and enhance the precision of immunological research, saving time and resources, and expediting novel discoveries and treatments.