Biomedical research is becoming more multi-disciplined to understand and develop treatments for complex diseases. For this reason, the integration of multiple omics (multiomics) technologies has emerged as a powerful approach for unraveling the complexities of biological systems. Multiomics is described as the comprehensive analysis of various omics data types such as genomics, transcriptomics, proteomics, and epigenomics. It holds immense promise in advancing our understanding of health and disease and continues to be heavily invested in by private and government agencies. To achieve this potential, Sampled has developed the Global Integrated Analytical Biorepository (GIAB) to help researchers unlock the full potential of multiomics in research and discovery.
In this article, we look at how the GIAB can integrate these omics technologies, so that researchers can gain a comprehensive understanding of complex biological systems, unlocking new insights into health, disease, and drug development.
Table of Contents
The Value of Multiomics
- Genomics: Studies the entire set of DNA within an organism. It offers foundational insights into genetic variations and predispositions to diseases.
- Transcriptomics: Focuses on RNA transcripts produced by the genome. It sheds light on gene expression patterns and regulatory mechanisms under various conditions.
- Proteomics: Examines the entire set of proteins, including their modifications and interactions. It provides a direct measure of the functional molecules driving cellular processes.
- Metabolomics: Analyzes the complete set of metabolites, which are the end products of cellular processes. It reflects the physiological state of cells in real-time.
Key Benefits of a Multiomics Approach
The integration of these diverse datasets through a multiomics approach yields comprehensive insights that cannot be achieved by any single omics analysis. This holistic perspective enables researchers to:
- Unravel complex disease mechanisms by connecting genetic predispositions with phenotypic outcomes.
- Identify novel biomarkers and therapeutic targets by revealing the underlying molecular pathways.
- Accelerate drug discovery and development by providing a more precise understanding of drug mechanisms and patient responses.
Integrating these perspectives, multiomics provides a holistic view of biological systems. This approach enables researchers to uncover hidden connections, identify biomarkers, elucidate disease mechanisms, and discover novel therapeutic targets. It accelerates research in the discovery and pre-clinical phases, helping biopharmaceutical companies save time and resources by focusing on the most promising drug candidates.
How the GIAB supports Multiomics
At Sampled, we understand the transformative potential of multiomics at the research and discovery/pre-clinical stage. That’s why we offer a wide range of services tailored to support multiomic workflows. From sample collection and processing to sequencing and bioinformatics, we provide end-to-end solutions designed to meet the diverse needs of our clients.
Analytical Sample Processing
We offer a suite of analytical sample processing services, including sample aliquoting, DNA/RNA extraction, fractionation, normalization, and sample processing quality control (QC). In our aliquoting workflow, we handle samples received from various sources, ensuring proper storage throughout the handling process.
These critical first steps ensure the integrity and uniformity of biological samples, laying a solid foundation for downstream multiomics analyses. By employing stringent QC protocols, Sampled ensures the reliability and reproducibility of data generated from its repository, which is particularly important for research involved in clinical trials.
Sequencing
Our sequencing services give our clients invaluable insights into their samples, expediting academic, industrial, and clinical research. By partnering with key technology platform manufacturers such as 10X Genomics, Illumina and PacBio, Sampled facilitates a wide range of omics analyses, including whole genome sequencing (WGS), whole exome sequencing (WES), targeted sequencing, Sanger sequencing, RNA sequencing, methylation sequencing, and advanced proteomics.
This complete and comprehensive suite of sequencing services enables researchers to delve deep into the genetic, transcriptomic, and epigenetic landscapes of biological samples, uncovering novel insights into disease mechanisms, biomarker discovery, and personalized medicine.
Proteomics and Protein Biomarker Discovery
Through partnership with Olink, we offer advanced proteomics and analyses through the Explore HT and 3072 platforms, allowing researchers to dissect the functional aspects of biology and uncover novel biomarkers for disease diagnosis and treatment. The Explore HT platform allows levels of over 5400 proteins to be determined from minimal sample volume giving researchers unprecedented access to discover new biomarkers from a wide range of medical fields including but not limited to oncology, cardiology, neurology, inflammation, and diabetes.
Microarrays
Sampled’s GIAB also offers microarray services, including genotyping, transcriptome profiling, and methylation profiling arrays. These high-throughput platforms enable researchers to interrogate genetic, transcriptomic, and epigenomic variations on a genome-wide scale, facilitating the identification of disease-associated biomarkers, therapeutic targets, and molecular signatures. By harnessing the power of microarrays, Sampled empowers researchers to unravel the intricacies of complex diseases and accelerate drug discovery efforts.
Bioinformatics
In addition to its analytical capabilities, Sampled offers comprehensive bioinformatics services, including data analysis and custom reporting tailored to individual client needs. Sampled obtains data from its in-house analytics pipeline or directly from clients. The data is securely stored on the laboratory information management system (LIMS) and can be accessed through SampledSphere. We offer tailor data analysis to meet client-specific requirements, which vary based on sequencing or array types.
Outsourcing multiomics services to Sampled offers numerous benefits, including access to state-of-the-art technologies, expertise, and scalability. Our platforms are designed to streamline sample processing and analytical workflows, reducing turnaround times and maintaining sample integrity throughout the analysis pipeline. This efficiency ensures that you receive your results promptly, allowing you to move forward with your research without unnecessary delays.
In conclusion, the Global Integrated Analytical Biorepository represents a critical advancement in the era of multiomics, offering researchers unprecedented opportunities for discovery and innovation. By providing end-to-end support for multiomics workflows, Sampled empowers researchers to gain a comprehensive understanding of complex biological systems. This holistic approach paves the way for breakthroughs in disease diagnosis, treatment, and prevention, highlighting the benefits of outsourcing multiomics services to accelerate research. For those ready to explore the frontiers of multiomics, Sampled stands ready to guide you through this exciting journey, unlocking the mysteries of life one molecule at a time.
For more information on accelerating your research through outsourcing multiomics workflows, contact Sampled today and speak with one of our experts.
