How does the service work?
We are happy to announce that at Sampled, in addition to iPSC reprogramming and gene editing services, now offer iPSC-derived neuronal progenitor cell (NPC) differentiation services. NPCs are a progenitor population of cells that can differentiate into neuronal populations and can be used for studying physiology, disease phenotypes and drug testing.
Using a robust and reproducible method developed by Dr. Sally Temple at NeuroCell, iPSC-derived NPCs are generated in culture using guidance factors such as dual SMAD inhibition, to recapitulate the development of the forebrain and create NPCs that can be differentiated into forebrain neurons.
NPCs can be requested 3 ways
NPCs from a limited number of disease phenotypes are available off the shelf (Table 1)
Arrangements can be made for clients to provide iPSC of interest.
Tau Consortium iPSC lines
Table 1: Select Tau Consortium iPSC lines already validated for NPC production (see Karch et al, 2019)
|F12436.3||P301L/S||WT/WT (P301L family)|
All NPCs can be shipped globally. If you would like to get in touch with us, please use the form below: